Drug Standards
Apexbio Technology LLC Cefaclor 53994-73-3 5g
Cefaclor (CAS 53994-73-3) is a semi-synthetic cephalosporin antibiotic targeting penicillin-binding proteins (PBPs) It inhibits these enzymes thereby disrupting the bacterial cell wall biosynthesis pathway Cefaclor exerts its biological activity primarily through inhibition of the transpeptidation step in peptidoglycan synthesis In in vitro studies Cefaclor demonstrates bactericidal activity with minimal inhibitory concentration (MIC) values generally ranging from 1 g/mL to 16 g/mL depending on the bacterial species tested Based on these pharmacological properties Cefaclor holds research potential in the fields of antibiotic resistance profiling bacterial susceptibility testing and studies involving gram-positive and gram-negative bacterial infections
Medchemexpress LLC Diaveridine | 5355-16-8 | 99.8% | 1 G
Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor and an antibacterial agent, with a Ki of 11.5 nM for the wild type DHFR. This compound is intended for research use only.
- Dihydrofolate reductase (DHFR) inhibitor
- Antibacterial agent
- Ki of 11.5 nM for the wild type DHFR
- Molecular Weight: 260.29
- Formula: C13H16N4O2
- Appearance: Solid
- Color: White to off-white
- Purity: 99.79%
Apexbio Technology LLC Diltiazem HCl 33286-22-5 1g
Diltiazem HCl is a small-molecule inhibitor targeting L-type calcium channels predominantly located on cardiac and vascular smooth muscle cells It is designed to inhibit calcium influx thereby reducing intracellular calcium concentrations and regulating muscle contraction and cardiac conduction Diltiazem HCl exerts its biological activity primarily through blockade of L-type calcium channels resulting in vascular smooth muscle relaxation decreased myocardial contractility slowed cardiac conduction reduced heart rate and coronary artery dilation Based on these pharmacological properties Diltiazem HCl holds research potential in cardiovascular pharmacology specifically for studies investigating mechanisms underlying cardiac arrhythmias ischemic heart conditions hypertension and related therapeutic interventions
Sigma Aldrich Fine Chemicals Biosciences Metamizole sodium European Pharmacopoeia (EP) Reference Standard | 5907-38-0 |
Metamizole sodium European Pharmacopoeia (EP) Reference Standard | Mol Wt: 351.35 | 5907-38-0 |
Medchemexpress LLC Pyridostigmine bromide | 101-26-8 | 98.9% | 1 ML
Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor supplied as a 10 mM, 1 mL solution in DMSO. It is primarily used in cardiovascular disease research and has demonstrated various biological activities in both in vitro and in vivo studies.
- Orally active cholinesterase (ChE) inhibitor
- Enhances SH-SY5Y cell activity and mitochondrial activity at low concentrations
- Promotes accumulation of SH-SY5Y cells in the S phase
- Upregulates telomerase, p53, and DNMT1 genes
- Reduces acetylcholinesterase activity in mice
- Improves myocardial changes in a Chagas cardiomyopathy mouse model
Selleck Chemical LLC Tenofovir Disoproxil Fumarate S1400-1g
Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5 -triphosphate and after incorporation into DNA by DNA chain termination
Medchemexpress LLC Tebipenem pivoxil | 161715-24-8 | 99.7% | 497.63 | 10 MG
Tebipenem pivoxil is an orally active antibiotic that works against various pathogenic bacteria. It functions by binding to penicillin-binding protein (PBP), thereby inhibiting bacterial cell wall synthesis. It exhibits excellent antibacterial activity against a range of pathogenic bacteria.
- Orally active antibiotic
- Inhibits cell wall synthesis by binding to penicillin-binding protein (PBP)
- Exhibits excellent antibacterial activity against pathogenic bacteria
- Inhibits Gram-positive and Gram-negative bacteria with MIC50s below 64 μg/mL
- Significantly increased survival in sepsis mouse models
Medchemexpress LLC Mevastatin | 73573-88-3 | 390.51 | 1 ML
Mevastatin (Compactin) is the first HMG-CoA reductase inhibitor belonging to the statins class. It acts as a lipid-lowering agent, induces apoptosis, and arrests cancer cells in the G0/G1 phase. It also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. This compound exhibits antitumor activity and shows potential for treating cardiovascular diseases.
- HMG-CoA reductase inhibitor
- Lipid-lowering agent
- Induces apoptosis and arrests cancer cells in G0/G1 phase
- Increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels
- Exhibits antitumor activity
- Potential for cardiovascular diseases treatment
- Targets metabolic enzyme/protease, autophagy, apoptosis, and anti-infection pathways
- Research areas include infection, cardiovascular disease, neurological disease, metabolic disease, and cancer
Medchemexpress LLC Cefditoren Pivoxil | 117467-28-4 | MFCD00926593 | 99.3% | 620.72 | 50 MG
Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial. It shows enhanced stability against many common β lactamases and is active against both Gram-negative and Gram-positive organisms. This compound can be used in research for infectious diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
- Broad-spectrum, third-generation, oral cephalosporin antibacterial.
- Enhanced stability against many common β lactamases.
- Activity against Gram-negative and Gram-positive organisms.
- Useful in research for various infectious diseases.
Medchemexpress LLC Clopidogrel impurity 2 | 212838-70-5 | MFCD08457889 | 500mg
Clopidogrel impurity 2 is an impurity of Clopidogrel (HY-15283)
Selleck Chemical LLC Tandutinib (MLN518) 100mg 387867-13-2 CT 53518, NSC726292, MLN518
Tandutinib (MLN518, CT53518, NSC726292) is a potent FLT3 antagonist with IC50 of 0.22 ?M, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Binimetinib
Binimetinib (MEK162 ARRY-162 ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy Phase 3
Selleck Chemical LLC Eltanexor (KPT-8602) 2mg 1642300-52-4 ONO-7706ATG-016
Eltanexor (KPT-8602, ONO-7706,ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20?211?nM in 10 AML lines after 3 days exposure. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Octreotide acetate, 83150-76-9, MFCD08277638, 50 mg
MF: C51H70N10O12S2, MW: 1079.29, Synonyms: SMS 201995; Sandostatin. Solubility: 53.9645mg/mL in DMSO. Octreotide acetate (Sandostatin) is an octapeptide congener of native somatostatin, inhibits the secretion of insulin and glucagon. It reduces production of IGF-1 and IGF-2 by the liver by modulation of growth-hormone secretion from the pituitary gland.